افزایش ریسک دیابت در زمینه مصرف دوز بالای استاتین ها
June 21, 2011 (London, United Kingdom) — A meta-analysis of some of the more high-profile statin trials testing the effectiveness of high-dose therapy has revealed a significant increase in the risk of diabetes mellitus associated with statin use in high doses . Compared with moderate-dose therapy across five statin trials, investigators report that treatment with high-dose statins increased the risk of diabetes by 12%.
Senior investigator Dr Kausik Ray (St George’s University of London, UK) said that while there might be consequences from the raised blood glucose levels, researchers do not yet know what these long-term effects mean. The net benefit of high-dose statin therapy “is definitely in favor” of using the drugs, he said.
“One thing we do know is that there does appear to be a dose effect with statin therapy, with the risk of diabetes mellitus increasing with higher doses,” Ray told heartwire . “Statins have multiple effects and cause a number of changes. What we’re seeing is probably an off-target effect, and right now we have no obvious mechanisms. However, lowering LDL-cholesterol levels is probably more important than the increase in blood-sugar levels.”
In their analysis, the number of patients needed to treat with high-dose statin therapy to prevent one cardiovascular event was 155, whereas the number needed to treat to cause one case of new-onset diabetes mellitus was 498. Overall, high-dose statin therapy reduced the risk of cardiovascular events in their meta-analysis by 16% compared with low- or moderate-dose statin therapy.
The results of the study are published in the June 22, 2011 issue of the Journal of the American Medical Association.
به ادامه مطلب توجه فرماییدادامه مطلب
نوشته شده توسط دکتر جلال کریمی در شنبه بیست و دوم مرداد 1390 و ساعت